Serum thrombomodulin
نویسندگان
چکیده
منابع مشابه
Serum Thrombomodulin after Lung Resection
135 Received June 1, 2012; accepted September 3, 2012. Published online September 14, 2012; doi: 10.1620/tjem.228.135. Correspondence: Sumiko Maeda, M.D., Ph.D., Department of Thoracic Surgery, Tohoku University Hospital, 4-1 Seiryomachi, Aobaku, Sendai, Miyagi 980-8575, Japan. e-mail: [email protected] *Present address: Department of Thoracic Surgery, Tohoku University Hospital, 4-1 Seiry...
متن کاملClinical importance of thrombomodulin serum levels.
Thrombomodulin is a glycoprotein that can bind to thrombin and activate protein C, thus mitigating the effects of cytokines produced by inflammatory and immunological processes. The molecule exerts a protective function on endothelial cells. Thrombomodulin is cleaved to its soluble form by neutrophil elastase and by other substances produced during acute and chronic inflammatory responses, immu...
متن کاملClinical implications of serum thrombomodulin in PR3-ANCA-associated vasculitis
BACKGROUND Vascular injury is the main mechanism in pathophysiology of PR3-ANCA-associated vasculitis. Soluble serum thrombomodulin (sTM) is a membrane-bound receptor for thrombin expressed by vascular endothelial cells. - OBJECTIVE The aim of study was to determine the blood levels of sTM in patients with PR3-ANCA-associated vasculitis. MATERIAL AND METHODS Twenty five patients with Wegene...
متن کاملSoluble thrombomodulin activity and soluble thrombomodulin antigen in plasma.
Endothelial cell membrane-bound thrombomodulin (TM) plays a critical role as a cofactor in the protein C pathway, important in regulating coagulation as well as inflammation. Heterogeneous soluble TM fragments circulate in the plasma and are found at increased levels in various diseases such as cardiovascular disease and diabetes, and in ischemic and/or inflammatory endothelial injuries. The an...
متن کاملThrombomodulin and the brain
Neurology® 2012;78:1 In this issue of Neurology, Giwa et al.1 report robust expression of thrombomodulin (TM) in small vessel disease, i.e., in small brain arteries or arterioles that exhibit the typical hyalinized thickening characteristic of chronic hypertensive changes. Using immunohistochemistry of postmortem brain tissue, the authors demonstrate extensive presence of TM in these small arte...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1994
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780370419